The Nile on eBay The Causes of Molecular Evolution by John H. Gillespie
A unified theory that addresses the important problem of the origin and maintenance of genetic variation in natural populations.
FORMATPaperback LANGUAGEEnglish CONDITIONBrand New Publisher Description
This work provides a unified theory that addresses the important problem of the origin and maintenance of genetic variation in natural populations. With modern molecular techniques, variation is found in all species, sometimes at astonishingly high levels. Yet, despite these observations, the forces that maintain variation within and between species have been difficult subjects of study. Because they act very weakly and operate over vast time scales, scientistsmust rely on indirect inferences and speculative mathematical models. However, despite these obstacles, many advances have been made. The author's research in molecular genetics, evolution, andbio-mathematics has enabled him to draw on this work, and present a coherent and valuable view of the field. The book is divided into three parts. The first consists of three chapters on protein evolution, DNA evolution, and molecular mechanisms. This section reviews the experimental observations on genetic variation. The second part gives a unified treatment of the mathematical theory of selection in a fluctuating environment. The final two chapters combine the earlier assessments in atreatment of the scientific status of two competing theories for the maintenance of genetic variation. Steeped in the enormous advances population genetics has made over the past 25 years, this book hasproven highly popular among human geneticists, biologists, evolutionary theorists, and bio-mathematicians.
Author Biography
John H. Gillespie is a professor of evolution at the University of California, Davis.
Table of Contents
1: Protein Evolution2: DNA Evolution3: The Molecular Clock4: Selection in a Fluctuating Environment5: Strong-Selection, Weak-Mutation Approximations6: Neutral Allele Theories7: Selection Theories
Review
"John Gillespie has thought harder than anyone else about the subtleties of the ways in which natural selection can bring about variation and evolution at the molecular level, and he has an enviable command of the theoretical and empirical literature on molecular evolution. [His book] deserves the careful attention of everyone interested in this field....Well written and informative." --Science"I like this book, and it is valuable to have many elements of the debate under one cover....This work will begin to counter the influence that defenders of the neutral theory have enjoyed over the past decade....A timely contribution which will promote interest in the study of adaptation at the molecular level." --Nature"Presents a unified theory that tackles the important current problem of the origin and maintenance of the genetic variation found in natural populations. Consideration of the great advances made in the discipline of population genetics makes this of interest to many readers." --Choice"Gillespie provides the first thorough assessment of the success of selectionist and neutralist arguments in explaining the data on genetic variation." --The Times Higher Education Supplement"Examines the whole question of molecular evolution, with reference to both experimental and mathematical approaches. The layout of the book allows the three parts to be read independently, which may be useful for those not mathematically inclined....Recommended for geneticists, biologists, and evolutionary theorists." --Animal Breeding Abstracts"Students in molecular evolution will welcome this book....An initial attempt to introduce realistic assumptions into current models of molecular evolution and contains many stimulating and often provocative ideas." --Laurent Excoffier (University of Geneva), Human Biology"John Gillespie has thought harder than anyone else about the subtleties of the ways in which natural selection can bring about variation and evolution at the molecular level, and he has an enviable command of the theoretical and empirical literature on molecular evolution. [His book] deserves the careful attention of everyone interested in this field....Well written and informative." --Science"I like this book, and it is valuable to have many elements of the debate under one cover....This work will begin to counter the influence that defenders of the neutral theory have enjoyed over the past decade....A timely contribution which will promote interest in the study of adaptation at the molecular level." --Nature"Presents a unified theory that tackles the important current problem of the origin and maintenance of the genetic variation found in natural populations. Consideration of the great advances made in the discipline of population genetics makes this of interest to many readers." --Choice"Gillespie provides the first thorough assessment of the success of selectionist and neutralist arguments in explaining the data on genetic variation." --The Times Higher Education Supplement"Examines the whole question of molecular evolution, with reference to both experimental and mathematical approaches. The layout of the book allows the three parts to be read independently, which may be useful for those not mathematically inclined....Recommended for geneticists, biologists, and evolutionary theorists." --Animal Breeding Abstracts"Students in molecular evolution will welcome this book....An initial attempt to introduce realistic assumptions into current models of molecular evolution and contains many stimulating and often provocative ideas." --Laurent Excoffier (University of Geneva), Human Biology
Long Description
This work provides a unified theory that addresses the important problem of the origin and maintenance of genetic variation in natural populations. With modern molecular techniques, variation is found in all species, sometimes at astonishingly high levels. Yet, despite these observations, the forces that maintain variation within and between species have been difficult subjects of study. Because they act very weakly and operate over vast time scales, scientistsmust rely on indirect inferences and speculative mathematical models. However, despite these obstacles, many advances have been made. The author's research in molecular genetics, evolution, and bio-mathematics has enabled him to draw on this work, and present a coherent and valuable view of the field.The book is divided into three parts. The first consists of three chapters on protein evolution, DNA evolution, and molecular mechanisms. This section reviews the experimental observations on genetic variation. The second part gives a unified treatment of the mathematical theory of selection in a fluctuating environment. The final two chapters combine the earlier assessments in a treatment of the scientific status of two competing theories for the maintenance of genetic variation. Steepedin the enormous advances population genetics has made over the past 25 years, this book has proven highly popular among human geneticists, biologists, evolutionary theorists, and bio-mathematicians.
Review Text
"John Gillespie has thought harder than anyone else about the subtleties of the ways in which natural selection can bring about variation and evolution at the molecular level, and he has an enviable command of the theoretical and empirical literature on molecular evolution. [His book] deserves the careful attention of everyone interested in this field....Well written and informative." --Science"I like this book, and it is valuable to have many elements of the debate under one cover....This work will begin to counter the influence that defenders of the neutral theory have enjoyed over the past decade....A timely contribution which will promote interest in the study of adaptation at the molecular level." --Nature"Presents a unified theory that tackles the important current problem of the origin and maintenance of the genetic variation found in natural populations. Consideration of the great advances made in the discipline of population genetics makes this of interest to many readers." --Choice"Gillespie provides the first thorough assessment of the success of selectionist and neutralist arguments in explaining the data on genetic variation." --The Times Higher Education Supplement"Examines the whole question of molecular evolution, with reference to both experimental and mathematical approaches. The layout of the book allows the three parts to be read independently, which may be useful for those not mathematically inclined....Recommended for geneticists, biologists, and evolutionary theorists." --Animal Breeding Abstracts"Students in molecular evolution will welcome this book....An initial attempt to introduce realistic assumptions into current models of molecular evolution and contains many stimulating and often provocative ideas." --Laurent Excoffier (University of Geneva), Human Biology"John Gillespie has thought harder than anyone else about the subtleties of the ways in which natural selection can bring about variation and evolution at the molecular level, and he has an enviable command of the theoretical and empirical literature on molecular evolution. [His book] deserves the careful attention of everyone interested in this field....Well written and informative." --Science"I like this book, and it is valuable to have many elements of the debate under one cover....This work will begin to counter the influence that defenders of the neutral theory have enjoyed over the past decade....A timely contribution which will promote interest in the study of adaptation at the molecular level." --Nature"Presents a unified theory that tackles the important current problem of the origin and maintenance of the genetic variation found in natural populations. Consideration of the great advances made in the discipline of population genetics makes this of interest to many readers." --Choice"Gillespie provides the first thorough assessment of the success of selectionist and neutralist arguments in explaining the data on genetic variation." --The Times Higher Education Supplement"Examines the whole question of molecular evolution, with reference to both experimental and mathematical approaches. The layout of the book allows the three parts to be read independently, which may be useful for those not mathematically inclined....Recommended for geneticists, biologists, and evolutionary theorists." --Animal Breeding Abstracts"Students in molecular evolution will welcome this book....An initial attempt to introduce realistic assumptions into current models of molecular evolution and contains many stimulating and often provocative ideas." --Laurent Excoffier (University of Geneva), Human Biology
Review Quote
"Students in molecular evolution will welcome this book....An initialattempt to introduce realistic assumptions into current models of molecularevolution and contains many stimulating and often provocative ideas." --LaurentExcoffier (University of Geneva), Human Biology
Details ISBN0195092716 Author John H. Gillespie Short Title CAUSES OF MOLECULAR EVOLUTION Series Oxford Series in Ecology and Evolution Language English ISBN-10 0195092716 ISBN-13 9780195092714 Media Book Format Paperback Year 1994 Illustrations line figures, tables Edition Description Revised Position Professor at Center for Population Biology Imprint Oxford University Press Inc Place of Publication New York Country of Publication United States Affiliation Professor at Center for Population Biology, University of California, Davis DOI 10.1604/9780195092714 UK Release Date 1994-09-08 AU Release Date 1994-09-08 NZ Release Date 1994-09-08 US Release Date 1994-09-08 Publisher Oxford University Press Inc Publication Date 1994-09-08 DEWEY 574.87328 Audience Professional & Vocational Pages 352 We've got this
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